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1

Improved drug-like properties of therapeutic proteins by directed evolution

Buchanan, A., Ferraro, F., Rust, S., Sridharan, S., Franks, R., Dean, G., McCourt, M., Jermutus, L., Minter, R.

Journal:

Protein Engineering Design and Selection

Year:

2012

Language:

english

File:

PDF, 420 KB

english, 2012

2

Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G Protein Biased Ligands at the Apelin Receptor

Nyimanu, Duuamene, Kuc, Rhoda E., Williams, Thomas L., Bednarek, Maria, Ambery, Philip, Jermutus, Lutz, Maguire, Janet J., Davenport, Anthony P.

Journal:

Year:

2019

Language:

english

File:

PDF, 3.17 MB

english, 2019

3

Parallel, high-throughput purification of recombinant antibodies for in vivo cell assays

David Bannister, Andrew Wilson, Leah Prowse, Meg Walsh, Rob Holgate, Lutz Jermutus, Trevor Wilkinson

Journal:

Biotechnology and Bioengineering

Year:

2006

Language:

english

File:

PDF, 357 KB

english, 2006

4

Isolation of a Small-Molecule Inhibitor of the Antiapoptotic Protein Bcl-xL from a DNA-Encoded Chemical Library

Samu Melkko, Luca Mannocci, Christoph E. Dumelin, Alessandra Villa, Roberto Sommavilla, Yixin Zhang, Markus G. Grütter, Nadine Keller, Lutz Jermutus, Ronald H. Jackson, Jörg Scheuermann, Dario Neri

Journal:

Year:

2010

Language:

english

File:

PDF, 916 KB

english, 2010

5

Recent advances in producing and selecting functional proteins by using cell-free translation

Lutz Jermutus, Lyubov A Ryabova, Andreas Plückthun

Journal:

Current Opinion in Biotechnology

Year:

1998

Language:

english

File:

PDF, 1.27 MB

english, 1998

6

Ligand binding of a ribosome-displayed protein detected in solution at the single molecule level by fluorescence correlation spectroscopy

Lutz Jermutus, Reto Kolly, Zeno Földes-Papp, Jozef Hanes, Rudolf Rigler, Andreas Plückthun

Journal:

European Biophysics Journal

Year:

2002

Language:

english

File:

PDF, 42 KB

english, 2002

7

Ligand binding of a ribosome-displayed protein detected in solution at the single molecule level by fluorescence correlation spectroscopy

Lutz Jermutus, Reto Kolly, Zeno Földes-Papp, Jozef Hanes, Rudolf Rigler, Andreas Plückthun

Journal:

European Biophysics Journal

Year:

2002

Language:

english

File:

PDF, 116 KB

english, 2002

8

Creating and evaluating protein diversity

Lutz Jermutus, Joelle Pelletier

Journal:

Current Opinion in Biotechnology

Year:

2001

Language:

english

File:

PDF, 38 KB

english, 2001

9

Selection of hapten-specific single-domain antibodies from a non-immunized llama ribosome display library

Kerrm Y.F Yau, Maria A.T Groves, Shenghua Li, Claudia Sheedy, Hung Lee, Jamshid Tanha, C.Roger MacKenzie, Lutz Jermutus, J.Christopher Hall

Journal:

Journal of Immunological Methods

Year:

2003

Language:

english

File:

PDF, 986 KB

english, 2003

10

Affinity maturation of a VHH by mutational hotspot randomization

Kerrm Y.F. Yau, Ginette Dubuc, Shenghua Li, Tomoko Hirama, C. Roger MacKenzie, Lutz Jermutus, J. Christopher Hall, Jamshid Tanha

Journal:

Journal of Immunological Methods

Year:

2005

Language:

english

File:

PDF, 196 KB

english, 2005

11

Harnessing phage and ribosome display for antibody optimisation

Patrick Dufner, Lutz Jermutus, Ralph R. Minter

Journal:

Trends in Biotechnology

Year:

2006

Language:

english

File:

PDF, 386 KB

english, 2006

12

Ribosome display: an in vitro method for selection and evolution of antibodies from libraries

Christiane Schaffitzel, Jozef Hanes, Lutz Jermutus, Andreas Plückthun

Journal:

Journal of Immunological Methods

Year:

1999

Language:

english

File:

PDF, 541 KB

english, 1999

13

How do you find new drugs using polypeptide display?

Lutz Jermutus, Jane K Osbourn

Journal:

Trends in Biotechnology

Year:

2000

Language:

english

File:

PDF, 60 KB

english, 2000

14

Current methods for the generation of human antibodies for the treatment of autoimmune diseases

Jane Osbourn, Lutz Jermutus, Alex Duncan

Journal:

Drug Discovery Today

Year:

2003

Language:

english

File:

PDF, 113 KB

english, 2003

15

Expression of high-affinity human antibody fragments in bacteria

Rouet, Romain, Lowe, David, Dudgeon, Kip, Roome, Brendan, Schofield, Peter, Langley, David, Andrews, John, Whitfeld, Peter, Jermutus, Lutz, Christ, Daniel

Journal:

Nature Protocols

Year:

2012

Language:

english

File:

PDF, 471 KB

english, 2012

16

In vitro DNA recombination by L-Shuffling during ribosome display affinity maturation of an anti-Fas antibody increases the population of improved variants

Chodorge, M., Fourage, L., Ravot, G., Jermutus, L., Minter, R.

Journal:

Protein Engineering Design and Selection

Year:

2008

Language:

english

File:

PDF, 442 KB

english, 2008

17

Comparison of Escherichia coli and rabbit reticulocyte ribosome display systems

Jozef Hanes, Lutz Jermutus, Christiane Schaffitzel, Andreas Plückthun

Journal:

Year:

1999

Language:

english

File:

PDF, 294 KB

english, 1999

18

Disordered C-terminal domain of tyrosyl-tRNA synthetase: Secondary structure prediction

Lutz Jermutus, Valérie Guez, Hugues Bedouelle

Journal:

Year:

1999

Language:

english

File:

PDF, 168 KB

english, 1999

19

In Vitro Selection for Catalytic Activity with Ribosome Display

Amstutz, Patrick, Pelletier, Joelle N., Guggisberg, Armin, Jermutus, Lutz, Cesaro-Tadic, Sandro, Zahnd, Christian, Plückthun, Andreas

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 222 KB

english, 2002

20

Structure-based chimeric enzymes as an alternative to directed enzyme evolution: phytase as a test case

Lutz Jermutus, Michel Tessier, Luis Pasamontes, Adolphus P.G.M van Loon, Martin Lehmann

Journal:

Journal of Biotechnology

Year:

2001

Language:

english

File:

PDF, 488 KB

english, 2001

21

Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis

Minter, RR, Cohen, ES, Wang, B, Liang, M, Vainshtein, I, Rees, G, Eghobamien, L, Harrison, P, Sims, DA, Matthews, C, Wilkinson, T, Monk, P, Drinkwater, C, Fabri, L, Nash, A, McCourt, M, Jermutus, L, R

Journal:

British Journal of Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.77 MB

english, 2013

22

Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

Revell, Jefferson D., Lund, Per-Eric, Linley, John E., Metcalfe, Jacky, Burmeister, Nicole, Sridharan, Sudharsan, Jones, Clare, Jermutus, Lutz, Bednarek, Maria A.

Journal:

Year:

2013

Language:

english

File:

PDF, 782 KB

english, 2013

23

Ribosome Display Efficiently Selects and Evolves High-Affinity Antibodies in vitro from Immune Libraries

Jozef Hanes, Lutz Jermutus, Susanne Weber-Bornhauser, Hans Rudolf Bosshard and Andreas Pluckthun

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.58 MB

english, 1998

24

Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries

Hanes, J., Jermutus, L., Weber-Bornhauser, S., Bosshard, H. R., Pluckthun, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 277 KB

english, 1998

25

A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency

Chodorge, M, Züger, S, Stirnimann, C, Briand, C, Jermutus, L, Grütter, M G, Minter, R R

Journal:

Cell Death & Differentiation

Year:

2012

Language:

english

File:

PDF, 634 KB

english, 2012

26

Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression

Buchanan, Andrew, Clementel, Veronica, Woods, Rob, Harn, Nicholas, Bowen, Michael A, Mo, Wenjun, Popovic, Bojana, Bishop, Steven M., Dall’Acqua, William, Minter, Ralph, Jermutus, Lutz, Bedian, Vahe

Journal:

Year:

2013

Language:

english

File:

PDF, 1013 KB

english, 2013

27

A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions

Grutter, C., Wilkinson, T., Turner, R., Podichetty, S., Finch, D., McCourt, M., Loning, S., Jermutus, L., Grutter, M. G.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 851 KB

english, 2008

28

Unbinding forces of single antibody-antigen complexes correlate with their thermal dissociation rates

Schwesinger, F., Ros, R., Strunz, T., Anselmetti, D., Guntherodt, H.-J., Honegger, A., Jermutus, L., Tiefenauer, L., Pluckthun, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 224 KB

english, 2000

29

Probing a protein-protein interaction by in vitro evolution

Thom, G., Cockroft, A. C., Buchanan, A. G., Joberty Candotti, C., Cohen, E. S., Lowne, D., Monk, P., Shorrock-Hart, C. P., Jermutus, L., Minter, R. R.

Journal:

Proceedings of the National Academy of Sciences

Year:

2006

Language:

english

File:

PDF, 1.13 MB

english, 2006

30

The effect of pH dependence of antibody-antigen interactions on subcellular trafficking dynamics

Devanaboyina, Siva Charan, Lynch, Sandra M, Ober, Raimund J, Ram, Sripad, Kim, Dongyoung, Puig-Canto, Alberto, Breen, Shannon, Kasturirangan, Srinath, Fowler, Susan, Peng, Li, Zhong, Haihong, Jermutus

Journal:

Year:

2013

Language:

english

File:

PDF, 1.78 MB

english, 2013

31

A variant human IgG1-Fc mediates improved ADCC

Stewart, R., Thom, G., Levens, M., Guler-Gane, G., Holgate, R., Rudd, P. M., Webster, C., Jermutus, L., Lund, J.

Journal:

Protein Engineering Design and Selection

Year:

2011

Language:

english

File:

PDF, 335 KB

english, 2011

32

Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor

Ravn, P., Madhurantakam, C., Kunze, S., Matthews, E., Priest, C., O'Brien, S., Collinson, A., Papworth, M., Fritsch-Fredin, M., Jermutus, L., Benthem, L., Gruetter, M., Jackson, R. H.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 3.20 MB

english, 2013

33

An improved method for an efficient and easily accessible eukaryotic ribosome display technology

Douthwaite, J.A., Groves, M.A., Dufner, P., Jermutus, L.

Journal:

Protein Engineering Design and Selection

Year:

2005

Language:

english

File:

PDF, 253 KB

english, 2005

34

Tailoring in vitro evolution for protein affinity or stability

Jermutus, L., Honegger, A., Schwesinger, F., Hanes, J., Pluckthun, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 461 KB

english, 2001

35

Identification of cyclic peptides able to mimic the functional epitope of IgG1-Fc for human Fc RI

Bonetto, S., Spadola, L., Buchanan, A. G., Jermutus, L., Lund, J.

Journal:

The FASEB Journal

Year:

2008

Language:

english

File:

PDF, 419 KB

english, 2008

36

Challenges and opportunities for non-antibody scaffold drugs

Vazquez-Lombardi, Rodrigo, Phan, Tri Giang, Zimmermann, Carsten, Lowe, David, Jermutus, Lutz, Christ, Daniel

Journal:

Drug Discovery Today

Year:

2015

Language:

english

File:

PDF, 6.91 MB

english, 2015

37

Sustained peripheral depletion of amyloid- with a novel form of neprilysin does not affect central levels of amyloid-

Henderson, S. J., Andersson, C., Narwal, R., Janson, J., Goldschmidt, T. J., Appelkvist, P., Bogstedt, A., Steffen, A.-C., Haupts, U., Tebbe, J., Freskgard, P. O., Jermutus, L., Burrell, M., Fowler, S

Journal:

Year:

2014

Language:

english

File:

PDF, 670 KB

english, 2014

38

Tailored amino acid diversity for the evolution of antibody affinity

González-Muñoz, Andrea, Bokma, Evert, O’Shea, Desmond, Minton, Kevin, Strain, Martin, Vousden, Katherine, Rossant, Christine, Jermutus, Lutz, Minter, Ralph

Journal:

Year:

2012

Language:

english

File:

PDF, 1.88 MB

english, 2012

39

Tailoring in vitro evolution for protein affinity or stability

Journal:

Proceedings of the National Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 461 KB

english, 2001

40

Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling

Galon-Tilleman, Hadas, Yang, Hong, Bednarek, Maria A., Spurlock, Sandra M., Paavola, Kevin J., Ko, Brian, To, Carmen, Luo, Jian, Tian, Hui, Jermutus, Lutz, Grimsby, Joseph, Rondinone, Cristina M., Kon

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 1.09 MB

english, 2017

41

Inhibition of T-cell activation by the CTLA4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease

Herrera, Marcela, Söderberg, Magnus, Sabirsh, Alan, Valastro, Barbara, Mölne, Johan, Santamaria, Beatriz, Valverde, Angela M., Guionaud, Silvia, Heasman, Stephanie, Bigley, Alison, Jermutus, Lutz, Ron

Journal:

American journal of physiology. Renal physiology

Year:

2017

Language:

english

File:

PDF, 2.11 MB

english, 2017

42

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor

Ge, Xuecai, Yang, Hong, Bednarek, Maria A., Galon-Tilleman, Hadas, Chen, Peirong, Chen, Michael, Lichtman, Joshua S., Wang, Yan, Dalmas, Olivier, Yin, Yiyuan, Tian, Hui, Jermutus, Lutz, Grimsby, Josep

Journal:

Cell Metabolism

Year:

2017

Language:

english

File:

PDF, 2.06 MB

english, 2017

43

Patterns of Estimated Glomerular Filtration Rate and Albuminuria in Relation to Progression to Serious Outcomes: Hospitalization for Infection, Major Adverse Cardiovascular Events and Renal Failure

Pritchard, N, Jenkins-Jones, S, Berni, E, Jermutus, L, Jain, M, Ambery, P, Currie, CJ

Journal:

Value in Health

Year:

2017

Language:

english

File:

PDF, 58 KB

english, 2017

44

MEDI0382, a GLP-1-glucagon receptor dual agonist, meets safety and tolerability endpoints in a single-dose, healthy-subject, randomised, phase 1 study

Ambery, Philip D., Klammt, Sebastian, Posch, Maximillian G., Petrone, Marcella, Pu, Wenji, Rondinone, Cristina, Jermutus, Lutz, Hirshberg, Boaz

Journal:

British Journal of Clinical Pharmacology

Year:

2018

Language:

english

File:

PDF, 524 KB

english, 2018

45

Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s Disease

Webster, Carl I., Burrell, Matthew, Olsson, Lise-Lotte, Fowler, Susan B., Digby, Sarah, Sandercock, Alan, Snijder, Arjan, Tebbe, Jan, Haupts, Ulrich, Grudzinska, Joanna, Jermutus, Lutz, Andersson, Chr

Journal:

Year:

2014

Language:

english

File:

PDF, 2.66 MB

english, 2014

46

Hospital admissions for severe infections in people with chronic kidney disease in relation to renal disease severity and diabetes status

Berni, Ellen, Pritchard, Nicholas, Jenkins-Jones, Sara, Ambery, Philip, Jain, Meena, Jermutus, Lutz, Scott, Laura A., Currie, Craig J.

Journal:

Endocrinology, Diabetes & Metabolism

Year:

2018

Language:

english

File:

PDF, 770 KB

english, 2018

47

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway

Wang, Jun, Ferreira, Ricardo, Lu, Wanhua, Farrow, Samatha, Downes, Kate, Jermutus, Lutz, Minter, Ralph, Al-Lamki, Rafia S., Pober, Jordan S., Bradley, John R.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 2.69 MB

english, 2018

48

Major adverse cardiovascular events in people with chronic kidney disease in relation to disease severity and diabetes status

Currie, Craig J., Berni, Ellen R., Berni, Thomas R., Jenkins-Jones, Sara, Sinsakul, Marvin, Jermutus, Lutz, Ambery, Philip, Jain, Meena, Bjornstad, Petter

Journal:

Year:

2019

Language:

english

File:

PDF, 3.41 MB

english, 2019

49

Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans

Nyimanu, Duuamene, Kay, Richard G., Sulentic, Petra, Kuc, Rhoda E., Ambery, Philip, Jermutus, Lutz, Reimann, Frank, Gribble, Fiona M., Cheriyan, Joseph, Maguire, Janet J., Davenport, Anthony P.

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 4.14 MB

english, 2019

50

Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans

Nyimanu, Duuamene, Kay, Richard G., Sulentic, Petra, Kuc, Rhoda E., Ambery, Philip, Jermutus, Lutz, Reimann, Frank, Gribble, Fiona M., Cheriyan, Joseph, Maguire, Janet J., Davenport, Anthony P.

Journal:

Scientific Reports

Year:

2019

File:

PDF, 4.14 MB

2019